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'Hypertensive disorders of pregnancy are major causes of maternal morbidity and mortality, which have been investigated extensively. Currently, the search for biomarkers for several conditions including hypertensive disorders of pregnancy is a major area of research. In this month’s issue Yan-ting Xu and colleagues have examined the levels of transforming growth factor and its receptors in hypertensive disorders of pregnancy. Their work demonstrates that the transforming growth factor beta superfamily and its soluble receptors are potential biomarkers and predictors of the condition. Studies like this one will go a long way in the effort to overcome hypertensive disorders of pregnancy.'