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''The Editor’s pick for the October issue is a secondary analysis of data from the CLEOPATRE II study, which examined HPV prevalence in over 2000 women in Portugal. The authors used data from the CLEOPATRE II study to investigate the potential impact of the nonavalent HPV vaccine in the prevention of high-grade cervical lesions and cervical cancer in Portugal. Although it seems evident that a vaccine which covers more HPV subtypes will have a greater preventive effect, this study is important because it helps to build the case for economic investment by quantifying the extent of the preventive effect. The authors suggest that the nonavalent HPV vaccine could prevent over 90% of high-grade cervical lesions and cervical cancer in Portugal."