International Federation of Gynecology and Obstetrics

Researchers in the UK are one step closer to knowing why older women are more likely to produce abnormal eggs.

In older women, there were reduced levels of proteins called cohesins, which are essential for chromosomes to divide properly in order for fertilisation to take place, according to the team from Newcastle University.

Abnormal egg production is linked to infertility, miscarriage and certain conditions, including Down's Syndrome.

Writing in the journal Current Biology, the scientists said the study might help them develop ways to prevent cohesin loss.

Lead researcher Dr Mary Herbert, of the Centre for Life at Newcastle University, said: "Reproductive fitness in women declines dramatically from the mid-thirties onwards. Our findings point to cohesin being a major culprit in this."

"If we can understand this, we will be in a better position to know if there is any possibility of developing interventions to help reduce cohesin loss," she added.

"Undoubtedly, the best way for women to avoid this problem is to have their children earlier."

Recently, it was reported that the Human Fertilisation and Embryology Authority in the UK was considering paying egg donors up to £700 to try to promote donation and increase numbers.

Posted by David Smith