Breast cancer cells spread in gangs, study shows

When breast cancer cells spread, they move in units of tumor cells, a new study has indicated. 

Research from the Nationwide Children’s Hospital in Columbus, Ohio, found that many of the mutations driving recurrent tumours when they appear elsewhere were part of the original tumour.

Many experts believed the majority of mutations in recurrent tumours occurred prior to spreading, though these new theories contradict that line of thinking and could open up new solutions for stopping metastasis.

By comparing the metastasized tumours with original breast tumours, the researchers discovered that multiple different cells from the initial site broke away together, leading to the creation of new tumours.  

Only two women in the study had cancer-driving mutations in their recurrent tumours that were not seen in the original, while all of the metastasised tumours had mutations in the TP53 gene. The researchers believe these mutations could suggest breast cancer can spread. 

While the study does not offer direct evidence of group migration of human cancer, the similar attributes of metastasised and original tumours indicate that several cells travel together to remote sites.ADNFCR-2094-ID-801835853-ADNFCR