Study monitors proteins in IVF and spontaneous pregnancies

A new study has examined the difference in protein detection during the first half of gestation between IVF and spontaneous pregnancies.

Researchers from the University Hospital of Oulu in Finland monitored 110 women, 55 of which were IVF and 55 naturally conceived pregnancies.

Analysis using fluorescence 2-D gel electrophoreses, multidimensional liquid chromatography tandem mass spectrometry and label-free quantification was done at 11 and 19 gestational weeks.

The study found that differences in important placentation proteins disappeared by 19 weeks, with only pregnancy specific glycoprotein-1 remaining dissimilar.

Dr Mervi Haapsama, author on the study, said: "The functions of many of these proteins are unknown. Further research may help explain the root causes of adverse pregnancy outcomes associated with IVF pregnancy and suggest early, selective treatments."

Researchers from Ludwig Maximilians University in Munich, Germany, have found that a change in estrogenic hormones during pregnancy is linked to restless legs syndrome.
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