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This is the finding of a prospective cohort study led by the University of Southampton, UK.
BRCA mutations occur in either the BRCA1 or BRCA2 gene and are inherited. The mutations put women at greater risk of breast and ovarian cancers, with 45 to 90 per cent of women with the mutation developing breast cancer during their lifetime. This is compared to approximately 12.5 per cent of women in the general population who develop breast cancer in the UK.
Professor Diana Eccles, head of cancer sciences at the University of Southampton, said:
The comprehensive analysis was undertaken on 2,579 tumours from four types of gynaecological cancer and breast cancer. It is part of the Pan-Cancer Atlas, which aims to answer pressing questions about cancer and could pave the way for therapeutic studies in the future.
Rehan Akbani, associate professor of Bioinformatics & Computational Biology, said:
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