Duration: 2015 - 2021
Chaired by Professor Malcolm Munro, USA
What is Abnormal Uterine Bleeding (AUB)
AUB in the reproductive years, unrelated to pregnancy, is rarely life-threatening, but is frequently life altering due to a complex set of disorders that include abnormalities in endocrine, endometrial and hemostatic function and a number of structural anomalies that include polyps, adenomyosis and leiomyomas or fibroids. It is important to understand that many of the structural abnormalities may not contribute to the patient’s symptoms – they may lie asymptomatic while the cause or causes of the AUB may be elsewhere.
What are the challenges?
Determination of the causes of AUB in the reproductive years remains a major challenge for investigators, clinicians and educators.
Investigators have to conceive and then execute relevant bench and clinical investigation; clinicians must deal with the patient in their office or hospital and educators of medical students and postgraduate trainees such as residents and fellows are encumbered with the task of providing a mechanism for understanding AUB that facilitates proper investigation and therapy.
For a number of investigators and educators, it became apparent that there were at least two major impediments to dealing with these challenges.
1) a disjointed collection of poorly defined and inconsistently used terms and definitions that undermined effective communication among investigators, clinicians and trainees alike.
2) the absence of a system for classifying the potential causes, or contributors to AUB symptoms in a specific patient.
These circumstances lead to difficulties with the interpretation of both basic science research and clinical trials as since specimens and patients could be "contaminated" with potential confounders. As a result, in order to obtain clearly informative basic science as well as translational and clinical investigation, a comprehensive approach to both investigation and categorisation was needed.
Committee Members 2015-2018
Professor Rohana Hathtootuwa - Sri Lanka
Professor Alka Kriplani - Co-Chair, India
Dr Carlos Fuchtner - Ex officio, Bolivia
Professor Ian Fraser, Australia
Professor Hilary Critchley, UK
Dr Rebecca Tonye, Cameroon
Dr Mario Hidalgo, Spain
Dr Luis Bahamondes, Brazil